Research Talk: Finding structural neighbors in protein space from sequence data
Biologists often want to know the biological function of a protein, which is informed by the three-dimensional structure of a protein. In general, two proteins of similar structure will have similar biological function. But experimentally determining the structure of a protein is expensive, in terms of both time and money. By comparison, a computational method that can find proteins similar in structure to a protein sequence is cheap. In this talk, I will present a novel approach we are considering for finding structural neighbors of a protein given only its sequence, using protein fragment libraries.